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Gale_CA

Research Abstracts Online
January 2009 - March 2010

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University of Minnesota Twin Cities
Medical School
Department of Pediatrics

PI: Cheryl A. Gale

Polarity Establishment Mechanisms in Candida albicans

The Gale laboratory studies the molecular mechanisms of morphogenesis in the opportunistic fungal pathogen, Candida albicans. By using molecular and cell biological approaches, they hope to dissect the differences that underlie yeast- and hyphal-form growth and to understand how the filamentous hypha, in particular, facilitates tissue invasion. Specific research projects involve identifying and characterizing the role of hyphal tip-localized polarity proteins in morphogenesis, growth tropisms (directional growth in response to an environmental signal), and tissue invasion and virulence using in vitro tissue culture models as well as in vivo models of candidiasis. In addition, time-lapse fluorescence microscopy is being used to characterize the temporal and spatial localization requirements of polarity proteins throughout the cell cycle, during the transition between morphologic forms, and with alteration in hyphal growth direction.

Group Members

Christina Falgier, Graduate Student
Timothy Heisel, Staff
Sara Kegley, Undergraduate Student
Jennifer Norton, Staff
Rebecca Pulver, Graduate Student
Kendra Van Beusekom, Undergraduate Student