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January 2009 - March 2010

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University of Minnesota Twin Cities
College of Biological Sciences
Medical School
Department of Biochemistry, Molecular Biology, and Biophysics

PI: Timothy J. Griffin, Associate Fellow

Proteomic Analysis Using Mass Spectrometry

The mission of the Griffin laboratory is to develop, disseminate, and apply mass spectrometry-based tools for studying proteins and their role in cell signaling, regulation, and disease. This work is highly collaborative and interdisciplinary in nature, bringing together aspects of molecular and cellular biology, biochemistry, analytical chemistry, computer science, statistics, and the clinical sciences. One research interest within the lab is making new discoveries that will lead to better treatment of patients in the clinic. A current focus is using proteomics to discover and verify salivary proteins that could be used for the early detection and monitoring of oral cancer, as well as other cancers and disease. A second area of interest is studying basic mechanisms of cell signaling and regulation. A current focus is a collaborative project studying the target-of-rapamycin (TOR) protein, the main regulator of nutrient response and cell growth. A third research area is characterizing post-translationally modified proteins. A current focus is proteomic studies of protein carbonylation, a poorly understood modification associated with the aging process and a variety of diseases.

Group Members

Sri Bandhakavi, Research Associate
Xiaobing Chen, Visiting Researcher
Ebbing de Jong, Research Associate
Joel Kooren, Graduate Student
Pontus Lundemo, Visiting Researcher
Getiria Onsongo, Graduate Student
Mikel Roe, Graduate Student
Matthew D. Stone, Research Associate
Chuanning Tang, Visiting Researcher
Sue van Riper, Graduate Student