Research Abstracts Online
January 2009 - March 2010
University of Minnesota Twin Cities
School of Public Health
Division of Biostatistics
PI: Weihua Guan
The Genetic Epidemiology of Deterioration of Kidney Allograft Function
Despite improvements in one-year kidney allograft survival, chronic graft dysfunction (CGD) and subsequent late graft loss persists as major clinical problem. The objective of this research is to determine whether allelic variants of genes involved in regulation of immune response (via cytokines and chemokines), fibrosis, growth factors, vascular adhesion molecules, and hypertension are associated with CGD defined as (1) persistent 25% increase in serum creatinine from a baseline established at three months post-transplantation and (2) persistent 25% decline in estimated glomerular filtration rate (eGFR), in a racially diverse transplant population.
The first part of the study involves recipient candidate genes and the second involves the living donor genes. Understanding the genetic variants of potential determinants of CGD and eGFR may suggest better therapeutic approaches that extend the function of the kidney allografts. The research aims will be accomplished via a multicenter, prospective cohort of kidney transplant recipients enrolled in an ongoing NIH-funded study involving kidney allograft biopsies during deterioration of kidney function. By identifying genetic polymorphisms that impact CGD and eGFR, this study will help identify patients at risk and will help in the development of therapies targeting critical pathways.
Ann M. Brearley, Research Associate
David Schladt, Research Associate