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Research Abstracts Online
January 2009 - March 2010

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University of Minnesota Twin Cities
Medical School
Department of Microbiology

PI: Ashley T. Haase

Investigations Into HIV-1 Infection

This group is using MSI resources for two projects. In the first, the researchers are performing microarray analyses of early simian immunodeficiency virus (SIV) infections in natural vs. non-natural hosts. The researchers are investigating the differences in progression to disease in the two different kinds of host and are using it as a non-human primate model of HIV-1 infection in humans.

The second project investigates stage-specific gene expression signatures in HIV-1 infection. These gene expression signatures were found using microarray analysis of lymphatic tissue in various stages of HIV-1 infection. This research will provide insight into the molecular mechanisms underlying HIV-1 pathogenesis.

Group Members

Qingsheng Li, Research Associate
Anthony Smith, Research Associate
Ming Zeng, Graduate Student