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Research Abstracts Online
January 2009 - March 2010

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University of Minnesota Twin Cities
College of Biological Sciences
Medical School
Department of Biochemistry, Molecular Biology, and Biophysics

PI: Reuben S. Harris

Genomic Investigations of Mammalian AID/APOBEC Proteins

The APOBEC gene family provides a broad defense against various endogenous and exogenous viruses and transposable elements. This defense system seems to have evolved during the mammalian lineage, from one gene in mice to seven in humans. These researchers are undertaking a comparative analysis of the APOBEC locus in several organisms. This will allow them to understand how this important gene family evolved and how this evolution relates to the different functions of the APOBEC proteins of different organisms. The researchers use bioinformatics tools available at the CGL to help them assemble sequencing data from large-scale sequencing projects and to perform bioinformatics analyses of the resulting data. They also use a number of structural programs for their collaborative work with the group of Hiroshi Matsuo (Biochemistry, Molecular Biology, and Biophysics).

Group Members

John Albin, Graduate Student
Michael Carpenter, Research Associate
Zach Demorest, Graduate Student
Alison Land, Research Associate
Ming Li, Research Associate
Steve Offer, Graduate Student
Ben Schurhamer, Undergraduate Student
Mark Stenglein, Graduate Student