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Research Abstracts Online
January 2009 - March 2010

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University of Minnesota Twin Cities
Medical School
Department of Medicine

PI: Marshall I. Hertz
Co-PI: Jagadish Patil

Gene Expression Microarrays in Lung Rejection

Obliterative bronchiolotis (OB) is a fibroproliferative process that represents the most significant limiting factor for long-term survival in lung transplant recipients. OB occurs unpredictably and is undetectable in a preclinical state. In addition, the major risk factor for OB is acute rejection, which can only be diagnosed by invasive lung biopsies. Therefore, these researchers use microarrays to identify patterns of gene expression associated with acute rejection, with the goal to identify those patterns that can serve as biomarkers of risk for OB. The researchers are using resources at the Supercomputing Institute laboratories to load, normalize, and analyze their data.

Group Members

Joanne Dehnbostel, Graduate Student
Hongfei Guo, Faculty Collaborator
Adam Hofer, Graduate Student