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Research Abstracts Online
January 2009 - March 2010

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University of Minnesota Twin Cities
Medical School
Department of Laboratory Medicine and Pathlogy

PI: Kristen A. Hogquist
Co-PI: Stephen C. Jameson

Thymic Selection

T lymphocytes acquire their essential characteristics during development in the thymus.  These properties—clonal expression of antigen receptors, major histocompatibility complex (MHC) restriction, self-tolerance, and lineage specific effector function—are continually established in the thymus as progenitors develop throughout the life of the animal. These researchers study how MHC restriction and self-tolerance are imprinted using genetically engineered mouse models. Current approaches include flow cytometry, microarrays, and fluorescent imaging; the group uses the BSCL, CGL, and SDML.

Group Members

Sara E. Hamilton, Research Associate
Amy Moran, Graduate Student
Oludare Odumade, Research Associate
Jean Porter, Research Associate
Kensuke Takada, Research Associate
Ziaodan Wang, Research Associate
Michael Weinreich, Graduate Student
Yan Xing, Research Associate