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Hu_WS

Research Abstracts Online
January 2009 - March 2010

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University of Minnesota Twin Cities
Institute of Technology
Department of Chemical Engineering and Materials Science

PI: Wei-Shou Hu, Associate Fellow

Genomic and Proteomic Analysis of Cells and Tissues

These researchers are involved in several projects using the MSI laboratories. In one, they are using genomics and proteomics to investigate recombinant Chinese hamster ovary cells. These industrially important cells carry many desirable phenotypic traits, but the alterations at the genomic level that confer those traits are not well understood. The researchers are seeking a better understanding of those key genetic alterations, which will facilitate the development of new cells lines and new processes.

A second project concerns biosynthesis in Streptomyces, which are important microorganisms because they produce more than two-thirds of clinically used antibiotics, as well as other bioactive molecules. The goal of the project is to identify the possible positions of important genes on the regulatory hierarchy of secondary metabolism for these organisms, which would serve as a model for studying synthesis and regulation of a variety of industrially important natural products.

A third project uses data mining to analyze cell-culture manufacturing processes. The data archives of manufacturing plants may have valuable information that could enhance process robustness. This data-mining effort will aid in developing effective control strategies to ensure process consistency and high productivity.

Other projects include investigations into improving the ability to grow cells with desirable metabolic characteristics, a project to use data mining for insights into embryonic and induced pluripotent stem cell signaling, sequencing of the curdlan-producing strain Agrobacterium sp. ATCC31749.

Group Members

Sanny Arleen, Visiting Researcher
Lance Augustin, Visiting Researcher
Marlene Castro-Melchor, Graduate Student
Anushree Chatterjee, Graduate Student
Ju-Xin Chin, Bioprocessing Technology Center, National University of Singapore, Singapore
Song-Hui Chuah, Bioprocessing Technology Center, National University of Singapore, Singapore
Nitya M. Jacob, Graduate Student
Kathryn Johnson, Graduate Student
Huong Le, Graduate Student
Sarika Mehra, Collaborator
Bhanu Mulikutla, Graduate Student
Peter Morrin Nissom, Bioprocessing Technology Center, National University of Singapore, Singapore
Jason Derek Owens, Graduate Student
Navneet Rao, Research Associate
Shikha Sharma, Graduate Student
Kartik Subramanian, Graduate Student
Siguang Sui, Graduate Student
Kher Tan, Bioprocessing Technology Center, National University of Singapore, Singapore
Nandita Vishwanathan, Graduate Student
Andrew Yongky, Graduate Student
Faraaz Yusufi, Bioprocessing Technology Center, National University of Singapore, Singapore