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Research Abstracts Online
January 2009 - March 2010

Main TOC ....... College TOC

University of Minnesota Twin Cities
Medical School
Department of Therapeutic Radiology

PI: Susanta K. Hui

Interactive Image-guided Radiation Therapy Research

These researchers have three projects using the BSCL and SDVL. In the first, they are segmenting and creating a three-dimensional rendering of different computed tomography (CT) images of bone. They are also developing the three-dimensional finite element (FE) model for FE-based strength analysis using the program ABAQUS. Bone strength depends on quantitative properties (bone mass, bone density, and modulus of elasticity) as well as properties of bone quality such as the structure parameters of trabecular bone (trabecular orientation and thickness, length, number, and separation distances of trabeculae). This model will allow determination of patient bone quality, which will be eventually related to bone health.

The second project evaluates uncertainties in tomotherapy conformal prostate treatment due to inter-fraction organ variation. The researchers evaluated megavoltage CT (MVCT) images for reconstruction, comparing planned dose and delivered dose. They studied the clinical feasibility of a close feedback process for an image-guided adaptive process.

The final project investigates the effects of changing machine parameters and consequently the signal-to-noise ratio on MVCT image quality and resolution. The researchers have discovered that a slightly higher dose during an MVCT scan can improve image quality and resolution, and they are expanding their investigation to include more complex imaging tasks.

Group Members

Douglas Adams, Department of Orthopaedic Surgery, University of Connecticut Health Center, Farmington, Connecticut
Troy Dos Santos, Graduate Student
Manju Sharma, Research Associate