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Research Abstracts Online
January 2009 - March 2010

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University of Minnesota Twin Cities
Institute of Technology
Department of Chemical Engineering and Materials Science

PI: Yiannis N. Kaznessis, Fellow

Multiscale Models for Biomolecular Systems

Antimicrobial peptides (AMPs) are a promising new class of antibiotics that are believed to kill pathogens by permeabilizing their cell membranes. The present work focuses on protegrin, a particularly effective AMP derived from porcine leukocytes, believed to act primarily by forming octameric transmembrane pores. These researchers combine atomistic molecular dynamics simulations with Poisson-Boltmann calculations and Nernst-Planck theory to determine the mechanism of action of protegrin.

Group Members

Costas Billiouris, Graduate Student
Dan S. Bolintineanu, Graduate Student
Vassilios Sotiropoulos, Graduate Student
Poonam Srivastava, Collaborator
Ben Swiniarski, Graduate Student
Victor Vivcharuk, Collaborator
Katherine Volzing, Graduate Student
Emilia Wu, Collaborator