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Research Abstracts Online
January 2009 - March 2010

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University of Minnesota Twin Cities
Medical School
Department of Pediatrics

PI: Theresa A. Laguna

Biomarkers of Acute Lung Injury and Remodeling in Cystic Fibrosis and Endobronchitis

This researcher uses MSI resources for projects related to cystic fibrosis (CF), a lung disease characterized by structural damage to the airways and parenchyma. Chronic inflammation and infection lead to airway injury and remodeling, causing loss of lung function and shortened life expectancy. The project uses proteomics and metabolomics methods to analyze CF sputum from infants and children to detect and measure airway matrix constituents as well as to determine the proteomic/metabolomic profile of different phenotypes of CF patients.

Another project re-creates the Pseudomonas aeruginosa endobronchitis seen in human CF lung disease in a rat model of endobronchitis. The goal is to characterize the development of inflammation and fibrosis over time in these animals.

Urine, blood, bronchoalveolar lavage fluid, and lung tissue will be obtained at various time-points post-infection and analyzed for potential biomarker identification using proteomics and metabolomics methods. These animal biomarkers can then be compared to those in similar human disease (i.e. cystic fibrosis).

Group Member

Chris Wendt, Faculty Collaborator