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Research Abstracts Online
January 2009 - March 2010

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University of Minnesota Twin Cities
Medical School
Department of Laboratory Medicine and Pathlogy

PI: James B. McCarthy

Gene Expression Profiles in Melanoma and Prostate Cancer

The McCarthy laboratory studies the importance of the tumor microenvironment in tumor progression. It is well accepted that the microenvironment promotes tumor growth, survival, and resistance to therapy. The laboratory has focused on identifying key tumor cell receptors that sense the tumor microenvironment, with the goal of identifying these receptors as potential targets for therapy. Work in the laboratory (and others) has shown that an important aspect of the function of these receptors is the ability to modify gene expression. The researchers are using MSI resources to help identify signaling networks that may be important for sensing the microenvironment. Understanding how the receptors modify gene expression will yield important new information as to how specific receptors function to facilitate tumor progression, and the information may be used to either provide new targets or to stratify tumors according to their drug sensitivity.

Group Members

Jennifer Carlson, Graduate Student
Matt Price, Staff
Jianbo Yang, Research Associate