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Research Abstracts Online
January 2009 - March 2010

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University of Minnesota Twin Cities
College of Liberal Arts
Department of Psychology

PI: Matt McGue

GEDI: The Genes, Environment, and Development Initiative

The GEDI project builds on established longitudinal studies of twin families and adoptive families by adding measured genotypes at 660,000 SNP loci for about 8,000 participants. Environmental risk factors have been measured and both G x E and G x G interactions are included in complex models of substance-abuse phenotypes and measures of behavioral disinhibition. The large number of SNP loci means that considerable computational effort is required to test associations of the SNPs with traits. The group also uses permutation tests to confirm associations and to determine appropriate statistical significance levels.

Group Members

Saonli Basu, Faculty Collaborator
Brian Hicks, Research Associate
Robert M. Kirkpatrick, Graduate Student
Xiang Li, Graduate Student
Stephen M. Malone, Staff
Michael B. Miller, Staff