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Research Abstracts Online
January 2009 - March 2010

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University of Minnesota Twin Cities
College of Veterinary Medicine
Department of Veterinary Clinical Science

PI: Jaime Modiano
Co-PI: Subbaya Subramanian

Comparative Cancer Genetics

Like humans, domestic dogs develop cancer spontaneously. In fact, cancers account for more than 50% of the mortality in pet dogs. Some of the most common cancer types are homologous to those seen in humans. The genetic structure of dog breeds, the higher prevalence of some of these cancer types, and the compressed chronology of the disease allow researchers to establish the influence of heritable traits on etiology, pathogenesis, and biological behavior of cancer. Furthermore, it is apparent that specific traits in the germ line or in the tumor that are conserved in dogs and humans will represent pathogenetically significant events. These researchers are using complementary genome-wide approaches in various platforms to define factors or patterns associated with risk, ontogenetic, morphological, and molecular classification, and outcome of lymphoma, osteosarcoma, and hemangiosarcoma of dogs and humans. The researchers also use MSI resources for several other projects concerning canine cancer.

Group Members

Megan Duckett, Staff
Aric Frantz, Graduate Student
Sarah Highfill, Staff
Daisuke Ito, Research Associate
Timothy O’Brien, Faculty Collaborator
Tzu Lip Phang, University of Colorado Denver, Denver, Colorado
Sally Robinson, Graduate Student
Aaron Sarver, Research Associate
Milcah Scott, Staff
Leslie Sharkey, Faculty Collaborator