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Nelson_HH

Research Abstracts Online
January 2009 - March 2010

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University of Minnesota Twin Cities
Academic Health Center
Masonic Cancer Center

PI: Heather H. Nelson

EVER1/EVER2 Haplotypes and Cutaneous HPV Infection

Epidermodysplasia verruciformis, EV, is an inherited syndrome associated with development of large numbers of HPV-infected skin cancers. EV is attributable to inherited mutations in two genes: EVER1 (also called TMC6) and EVER2 (TMC8). Polymorphisms in these genes are unexplored susceptibility traits. This group’s analysis of a single SNP in the EVER2 gene suggests an association between the variant genotype and both HPV infection and skin cancer risk. They have expanded their genotyping to include haplotype tagging SNPs of both genes, and use software available at MSI to analyze haplotypes, HPV infection, and skin cancer risk.

Group Members

Lindsay Almquist, Graduate Student
Trina Kuriger, Staff