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Research Abstracts Online
January 2009 - March 2010

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University of Minnesota Twin Cities
College of Biological Sciences
Medical School
Department of Genetics, Cell Biology, and Development

PI: Laura P.W. Ranum

Genetic Mapping of a Novel Familial ALS Gene

In a simple autosomal dominant family, the goal of lineage analysis and a genome screen is to identify regions of the genome that are shared among affected individuals in the family. To enhance the power of the amyotrophic lateral sclerosis (ALS)-A family for informative linkage analysis, these researchers generated a panel of haploid cell lines for all available affected family members and other key individuals in the pedigree. This genome-wide panel of haploid cell lines generated over the past two and one-half years allows the researchers to directly establish and compare haplotypes for entire chromosomes among affected individuals. The results of this method allowed the researchers to directly identify regions that are shared by all affected family members and are thus candidate regions for the ALS-A gene, as well as regions that are clearly excluded. In addition to understanding ALS, an equally important goal of this project was to develop and validate the proposed haplotype genome screening strategy as a novel method to enhance the power of genetic mapping studies for other diseases.

Group Member

Katherine Dick Krueger, Graduate Student