University of Minnesota
University Relations
http://www.umn.edu/urelate
612-624-6868

Minnesota Supercomputing Institute


Log out of MyMSI
Rougvie_AE

Research Abstracts Online
January 2009 - March 2010

Main TOC ....... College TOC 1 ...... College TOC 2 ....... Next Abstract

University of Minnesota Twin Cities
College of Biological Sciences
Medical School
Department of Genetics, Cell Biology, and Development

PI: Ann E. Rougvie

Caenorhabditis Genetics Center

Temporal Control of Development in Caenorhabditis elegans

These researchers use MSI resources to study the nematode Caenorhabditis elegans, a developmentally simple organism. One goal is to collect, maintain, and distribute nematode strains to the international scientific community.

They are also studying C. elegans to understand how cells execute specific events at precise times during development. Specifically, they dissect the timing mechanism that restricts the differentiation of hypodermal cells to a time late in the life of the worm, the transition from the larval to adult form. The approach is to identify mutations that cause this event to occur at the wrong time during development, and then to study the genes defined by these mutations. These genes are referred to as "heterochronic” genes because their mutation alters the relative timing and sequence of many developmental events in the animal. The long-term goal of this research is to determine how developmental timing mechanisms are integrated with the spatial and sexual cues required for proper development of metazoans.

Group Members

Aric Daul, Staff
Tamar Resnick, Staff
Bradley Scutvick, Staff
Theresa Stiernagle, Staff