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Research Abstracts Online
January 2009 - March 2010

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University of Minnesota Twin Cities
Academic Health Center
Center for Drug Design

PI: Christine E. Salomon

Identification and Structural Characterization of Novel Natural Products From Terrestrial Actinobacteria

It is estimated that more than 60% of all currently used therapeutic drugs are derived from or inspired by natural products (secondary metabolites). These researchers are interested in exploring the chemical and biochemical diversity of antibiotics from soil bacteria to discover novel compounds that are bioactive, particularly against drug resistant pathogens. In collaboration with Linda Kinkel’s group (Department of Plant Pathology), this group is fermenting new strains of bacteria, making chemical extracts of the cell and fermentation broths, and analyzing these extracts for novel bioactivity. Bioassay guided fractionation is used to purify the active components and the structures are determined using NMR spectroscopy, mass spectrometry, semi-synthesis and chemical derivatization. The researchers are also interested in developing novel methods of identifying new natural products based on physico-chemical properties rather than biological activities.

Group Members

Michael Donald, Undergraduate Student
John Kurtz, Undergraduate Student
Yudi Rusman, Research Associate
Lori Schmidt, Research Associate
Dan Schneider, Undergraduate Student