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Research Abstracts Online
January 2009 - March 2010

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University of Minnesota Twin Cities
College of Biological Sciences
Medical School
Department of Biochemistry, Molecular Biology, and Biophysics

PI: Michel M. Sanders

The Biological Functions of the ZEB1 Transcription Factor

The long-term goal of this research is to understand how the ZEB1 transcription factor modulates gene activity and to clarify its biological functions. A necessary part of the project involves creating many mutations in the plasmid encoding ZEB1 as well as in various ZEB1 target promoters. The researchers are using Sequencer and Mac Vector, available at the BSCL and CGL, for this purpose. They are also performing microarray analyses and are using statistical programs and user-support assistance.

Group Member

Brian Sandri, Graduate Student