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SreevatsanS

Research Abstracts Online
January 2009 - March 2010

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University of Minnesota Twin Cities
College of Veterinary Medicine
Department of Veterinary Population Medicine

PI: Srinand Sreevatsan

Investigations of Infection Mechanisms

The principal focus of this group is to define the molecular mechanisms by which bacteria and viruses establish infection. The researchers’ interests surround several issues in host-pathogen interactions (termed the "host-pathogen dance”) with specific emphasis on the evolution of the pathogen and its adaptation to hosts. The translational aspect of these investigations is in the development of improved diagnostic tests and methods for microbial characterization and identification, as well as studies into new generations of antimicrobial vaccines and therapeutics.

A secondary focus is in the improvement of currently available diagnostic tools. As a result some investigations use state-of-the-art functional genomics, proteomics, and other molecular methods including the design of novel high affinity ligands and sensitive back-end detection methods. These are coupled with classical and modified extraction protocols to improve recovery of agents of interest for accurate diagnostics. The group is currently investigating the molecular diversity in mycobacteria, influenza, and developing high affinity ligands to prion proteins to investigate the pathogenesis and new therapeutic modalities for transmissible spongiform encephalopathies.

Group Members

Ahmed Abd-Allah, Graduate Student
Ramakrishnan Muthannan Andavar, Research Associate
Preethi Haran, Graduate Student
Harish K. Janagama, Graduate Student
Deepti Joshi, Graduate Student
Abirami Kugadas, Graduate Student
Elise Lamont, Graduate Student
Amanda Oliveira, Graduate Student
Madhumati Venugoal, Staff
Ping Wang, Faculty Collaborator
My Yang, Staff