Research Abstracts Online
January 2009 - March 2010
University of Minnesota Twin Cities
College of Biological Sciences
Department of Biochemistry, Molecular Biology, and Biophysics
PI: Gianluigi Veglia
Structural Modeling and Molecular Simulations of Membrane Proteins and Their Protein Complex Driven by NMR Data
Membrane proteins play vital roles in many cellular processes such as signal transduction, ion translocation and homeostasis. Membrane proteins structures and dynamics, and their interactions with other proteins are crucial to understanding related biological functions. High-resolution biophysical techniques, especially NMR, are employed in this group to study membrane proteins in lipid environments.
Based on experimental NMR data, the group uses computation techniques to build models of protein-protein complexes involving membrane proteins structures. They also perform classical molecular dynamics simulations in order to understand their structure and dynamics. These complexes models and simulations constitute a starting point to understand molecular mechanism of their function.
Kim Ha, Graduate Student
Larry Masterson, Graduate Student
Lei Shi, Graduate Student
Nathan Traaseth, Graduate Student
Yi Wang, Undergraduate Student