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Research Abstracts Online
January 2009 - March 2010

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University of Minnesota Twin Cities
Medical School
Department of Medicine

PI: Christine H. Wendt

Protein Biomarkers in Lung Allograft Rejection

Lung transplantation is an effective therapy for many end-stage lung diseases. Despite advances in immunosuppressive therapy, chronic rejection remains a leading cause of morbidity and mortality. This researcher studies bronchoalveolar lavage fluid to identify a biosignature of rejection since the small airways are the observable site of chronic rejection and are likely to yield a strong signal. The goal of this project is to identify and validate effective biomarkers for eventual use as diagnostic tools for the detection of chronic lung allograft rejection. The researcher is using proteomics resources at the CGL.