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YoungND_TiffinPL

Research Abstracts Online
January 2009 - March 2010

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University of Minnesota Twin Cities
College of Food, Agricultural, and Natural Resource Sciences
Department of Plant Pathology

PI: Nevin D. Young, Associate Fellow
Co-PI: Peter L. Tiffin

A Medicago truncatula HapMap as a Platform for Exploring the Genetics of Symbiosis

This project uses whole-genome association mapping (WGAM) to create a Medicago HapMap as a framework for discovering the genes and gene-systems that play a role in the contemporary evolution of symbiosis. In brief, approximately 400 diverse Medicago lines are being resequenced using next-generation sequencing technology in order to search for single nucleotide polymorphisms (SNPs), gene copy number variation, and insertion/deletion polymorphisms among the different Medicago lines. This massive database of SNPs and sequence variants will enable the discovery of genome segments with shared ancestry (haplotypes), which can then be used for statistical and data-mining techniques in the discovery of genotype/phenotype relationships involved in symbiosis. Because of the exceedingly high level of variant density discovery made possible through next generation sequencing, this GWAM strategy will approach single-gene level resolution.

Group Members

Antoine Branca, Research Associate
Arvind Bharti, Research Associate
Roman Briskine, Staff
Roxanne Denny, Staff
Tim Paape, Research Associate
Shelley (Xiaohong) Wang, Staff
Peng Zhou, Graduate Student