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January 2009 - March 2010

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University of Minnesota Twin Cities
Office of the Vice President for Research
Hormel Institute

PI: Jinhui Zhang

Mechanisms of Prostate Cancer Chemoprevention by Penta-galloyl-glucose Through Proteomics and Pharmacokinetic Approaches

The overall goal of this research project is to develop oriental herbal compound 1,2,3,4,-6-penta-O-galloyl-beta-D-glucose (PGG) for the chemoprevention of prostate cancer. Preliminary data showed that PGG possessed potent in vivo anti-tumor effects in a mouse lung cancer allograft model and human prostate xenograft model, but the in vivo mechanism(s) were not yet clear. This project uses a proteomics approach to identify the potential target(s) of PGG in the target organ prostate and a plasma and pharmacokinetics approach to determinate the plasma level and potential metabolites of PGG after oral administration. The samples are analyzed at the Mass Spectrometry and Proteomics Core Facility of the College of Biological Sciences. To view and analyze data generated by the instruments, the researchers use Analyst 1.4.2, ProteinPilot 3.0 and IPA software. The software allows the researchers to decipher the data generated by LC-MS/MS, to understand the in vivo mechanisms of PGG, and to facilitate the bench-to-bed translation.

Group Member

Li Li, Research Associate