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Research Abstracts Online
January 2010 - March 2011

Main TOC

Mayo Clinic College of Medicine
Department of Medical Oncology

PI: Matthew Ames

Population Pharmacokinetic Modeling of Anticancer and Other Therapeutic Agents Under Preclinical and Clinical Investigation

This population pharmacokinetic modeling project is being conducted in support of completed and ongoing clinical trials conducted by the Mayo Clinic Comprehensive Cancer Center. Through the use of the software program NONMEM, pharmacokinetic data obtained from preclinical and Phase 0–III studies are utilized to develop comprehensive compartmental models that describe the pharmacokinetic behavior of investigational drugs and their metabolites for the entire study population. The population-based models thus developed are utilized to quantify the pharmacokinetic variability exhibited between study subjects and explain it in terms of underlying differences in patient physiology. Moreover, depending on the available data, relationships between the pharmacokinetic model parameters and pharmacodynamic outcomes will also be investigated. Taken as a whole, the intent of this investigation is to utilize the population pharmacokinetic modeling approach to ascertain the influence of clinically relevant and measurable factors on the pharmacokinetics and pharmacodynamics of anticancer and other therapeutic agents with the ultimate goal of improving drug dosing guidelines on the individual patient level.

Group Members

Joel Reid, Co-Principal Investigator
Alexander Berg, Research Associate