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Research Abstracts Online
January 2010 - March 2011

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University of Minnesota Twin Cities
Medical School
Department of Medicine

PI: Daniel R. Boulware

Cryptococcal Optimal ART Timing Trial

Although antiretroviral therapy (ART) improves survival in persons with cryptococcal meningitis (CM) and AIDS, ART frequently elicits HIV immune reconstitution inflammatory syndrome (IRIS), an exaggerated and frequently deadly inflammatory reaction that complicates recovery from immunodeficiency. The pathogenesis of IRIS is poorly understood, and prediction of IRIS is not possible. These researchers have determined that certain biomarkers predispose AIDS patients to IRIS and are hoping to validate this finding. This could be an objective tool to stratify the risk of IRIS and death that might be used clinically to guide when to start ART or need for prophylactic interventions.

Group Members

Daniel J. Beisang, Graduate Student
Jonathan C. Jeschke, Research Associate
Bernd Rattenbacher, Research Associate
Julius R. SternJohn, Graduate Student
Irina Vlasova, Research Associate
Maximilian P. von Hohenberg, Undergraduate Student
Darin L. Wiesner, Research Associate