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Research Abstracts Online
January 2010 - March 2011

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University of Minnesota Twin Cities
Medical School
Department of Otolaryngology

PI: Sebahattin Cureoglu

Three-Dimensional Reconstruction of Endolymphatic Ducts From Specimens of Temporal Bone in Meniere's Disease

Endolymphatic hydrops is a typical finding of Meniere’s disease in histopathologic examination of temporal bones. An endolymphatic duct plays an important role in one of the causes of endolymphatic hydrops. It is difficult to reconstruct a three-dimensional image of the endolymphatic duct from a computed tomography scan, because it is very thin and surrounded by bone.

The purpose of this study was to reconstruct three-dimensional images of endolymphatic ducts from specimens of temporal bone and to investigate pathophysiological factors in Meniere’s disease. The temporal bones were obtained from the collection of the University of Minnesota’s Otopathology Laboratory. Entire serial sections of temporal bones were captured at a resolution of 150 pixels per inch, using a digital camera connected to a personal computer equipped with ACT-1 control software. Three-dimensional images of endolymphatic ducts were reconstructed using the software package AVIZO.