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Research Abstracts Online
January 2010 - March 2011

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University of Minnesota Twin Cities
College of Science and Engineering
Department of Chemical Engineering and Materials Science

PI: Kevin D. Dorfman, Associate Fellow

Modeling DNA Dynamics

The Dorfman group uses a mixture of theory, computation, and experiment to understand the transport properties of DNA. The primary research effort is focused on DNA electrophoresis in novel sieving matrices, which can provide order-of-magnitude increases in throughput and sensitivity. The second area of research is on single-stranded DNA, in particular DNAzyme catalysis, where they aim to correlate the mesoscale dynamics of these molecules with their biological activity. The primary tools are Brownian dynamics, stochastic kinetics, and molecular dynamics.

Group Members

Sarit Dutta, Graduate Student
Nabil Laachi, Graduate Student
Margaret Linak, Graduate Student
Ashwin P. Srisrishna, Supercomputing Institute Undergraduate Intern
Mingwei Tian, Undergraduate Student
Douglas R. Tree, Graduate Student
Yanwei Wang, Research Associate