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Research Abstracts Online
January 2010 - March 2011

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University of Minnesota Twin Cities
Medical School
Department of Laboratory Medicine and Pathology

PI: Michael A. Farrar

STAT5 and Early B Cell Factors and Their Role in Acute Lymphoblastic Leukemia

These researchers have previously shown that a constitutively active form of STAT5 induces acute lymphoblastic leukemia (ALL) though at low penetrance. More recently, they have identified several genes that are critical to B cell development that can increase the incidence of ALL induction. Current research has focused on identifying mechanisms involved in the induction of ALL by using microarray analysis. In addition, the researchers are hoping to use new techniques to examine correlations with human ALL, which will require analysis through programs like GeneSpring.

Group Members

Lynn Heltemes-Harris, Research Associate
Casey Katerndahl, Graduate Student
Kieng Bao Vang, Graduate Student
Mark Willette, Graduate Student