Research Abstracts Online
January 2010 - March 2011
University of Minnesota Twin Cities
of Laboratory Medicine and Pathology
PI: William B. Gleason, Fellow
Applications of High-Performance Computing to Biological Structure Problems
This work concerned experimental and theoretical structural modeling questions. It included x-ray crystallographic structure determination of protein/ligand complexes as well as simulation of such structures using docking and/or molecular dynamics studies. Systems of interest included glycosaminoglycan (e.g., heparin) interactions with proteins. These are important in blood coagulation as well as virtually all aspects of growth and development.