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Research Abstracts Online
January 2010 - March 2011

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University of Minnesota Twin Cities
College of Biological Sciences
Medical School
Department of Biochemistry, Molecular Biology, and Biophysics

PI: Timothy J. Griffin, Associate Fellow

Proteomic Analysis Using Mass Spectrometry

Work in this group involves the development and application of mass spectrometry-based tools to study proteins and proteomes. The goal of this work is to provide the necessary tools to enable the comprehensive characterization of the entire complement of proteins expressed within a cell, tissue or organism, in order to better understand basic mechanisms of biological function and disease. These tools must be capable of measuring the many properties of proteins that collectively determine their function. These properties include the quantitative levels of expressed proteins, sub-cellular localization, post-translational modifications, associations in non-covalent complexes and biochemical activity. Mass spectrometry provides a highly powerful tool that is capable of measuring these various protein properties, in a high-throughput manner. The development of these tools is highly interdisciplinary in nature, integrating front-end molecular biology and biochemical methods, protein and peptide chemistry, analytical separations, instrumental analysis, and back-end computational software for data processing.

Group Members

Sri Bandhakavi, Research Associate
Ebbing de Jong, Research Associate
Bryan Horrigan, Undergraduate Student
Kaylee Jamison, Undergraduate Student
Joel A. Kooren, Graduate Student
Getiria I. Onsongo, Graduate Student
Samuel Schmidt, Graduate Student
Matthew D. Stone, Research Associate
Chuanning Tang, Visiting Researcher
Pierre N. Tawfik, Undergraduate Student
Susan van Riper, Graduate Student