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Research Abstracts Online
January 2010 - March 2011

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University of Minnesota Twin Cities
College of Biological Sciences
Medical School
Department of Biochemistry, Molecular Biology, and Biophysics

PI: Reuben S. Harris

Genomic Investigations of Mammalian APOBEC Proteins

The APOBEC family of DNA deaminase proteins provides a broad defense against various endogenous and exogenous viruses and transposable elements. This defense system appears specific to mammals and the number of proteins between mammalian lineages varies tremendously. These researchers are undertaking a comparative analysis of these proteins. This will allow them to understand how this important innate defense system evolved and how it specialized in different mammals. They use the bioinformatics tools available at MSI to help assemble sequencing data from large-scale sequencing projects and to perform bioinformatics analyses of the resulting data. They also use structural data analysis tools for analyzing structures and generating images for presentations.

Group Members

John S. Albin, Graduate Student
Michael A. Carpenter, Research Associate
Zach Demorest, Graduate Student
Alison Land, Research Associate
Rebecca LaRue, Research Associate
Ming Li, Research Associate