Research Abstracts Online
January 2010 - March 2011
University of Minnesota Twin Cities
PI: Paul A. Iaizzo
Model Pacing in the Cardiac Veins
The effects of cardiac anatomy and pacing lead electrode locations in left ventricular cardiac veins on resultant pacing thresholds are not well understood. Therefore, in vitro thresholds measured in swine hearts were compared with electric fields simulated by a computational model of left ventricular venous pacing with varying vein diameters, fat thicknesses, and electrode positions. Modeled electric fields followed the same qualitative trends as the in vitro experiments. While electrode position affected pacing thresholds, vein diameters and epicardial fat thicknesses also influenced thresholds. Electrostatic field simulations can provide insight as to how cardiac anatomy and electrode locations affect thresholds by providing visualization of the electric field propagating through cardiac tissues during a pacing pulse. MSI resources are used to generate the electric field model in the coronary veins and surrounding tissue using Maxwell three-dimensional modeling software.
Julianne H. Eggum, Graduate Student