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Research Abstracts Online
January 2010 - March 2011

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University of Minnesota Twin Cities
Medical School
Department of Surgery

PI: Paul A. Iaizzo

Model Pacing in the Cardiac Veins

The effects of cardiac anatomy and pacing lead electrode locations in left ventricular cardiac veins on resultant pacing thresholds are not well understood. Therefore, in vitro thresholds measured in swine hearts were compared with electric fields simulated by a computational model of left ventricular venous pacing with varying vein diameters, fat thicknesses, and electrode positions. Modeled electric fields followed the same qualitative trends as the in vitro experiments. While electrode position affected pacing thresholds, vein diameters and epicardial fat thicknesses also influenced thresholds. Electrostatic field simulations can provide insight as to how cardiac anatomy and electrode locations affect thresholds by providing visualization of the electric field propagating through cardiac tissues during a pacing pulse. MSI resources are used to generate the electric field model in the coronary veins and surrounding tissue using Maxwell three-dimensional modeling software.

Group Member

Julianne H. Eggum, Graduate Student