Research Abstracts Online
January 2010 - March 2011
University of Minnesota Twin Cities
School of Public Health
Division of Epidemiology and Community Health
PI: Ajay Israni
Genomics of Kidney Transplantation
End stage renal disease (ESRD) is a growing and expensive problem in the United States, costing in excess of $25 billion in 2002 alone. For treating ESRD, kidney transplantation is more cost-effective than long-term dialysis. Despite improvements in one-year kidney allograft survival, late graft loss (LGL) persists as a major clinical problem. Both immune and nonimmune mechanisms contribute to chronic allograft dysfunction (CGD) and subsequent LGL. Although many correlates of allograft function are now known, there remains extensive unexplained variation in occurrence of LGL.
These researchers are using a genetic epidemiology approach, using an ongoing, large, prospective cohort of kidney transplant recipients enrolled in a study funded by the NIH. All subjects in the DeKAF study will undergo kidney allograft biopsies for a deterioration of renal function defined by greater than 25% persistent increase in serum creatinine from a baseline established at three months post-transplant or new onset proteinuria. The DeKAF study is designed to classify causes of CGD, using clinical information and biopsy findings. The researchers are using MSI resources to help determine how genetic predisposition may help to explain the outcomes defined in the DeKAF study.
John Holmes, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania
Jennifer Vigliaturo, Research Associate
Winston Wildebush, Research Associate