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Research Abstracts Online
January 2010 - March 2011

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University of Minnesota Twin Cities
College of Veterinary Medicine
Department of Veterinary Biomedical Sciences

PI: Yinduo Ji

Novel Essential Regulator of Staphylococcus aurens

Staphylococcus aureus is a major community- and hospital-acquired pathogen causing superficial skin and life-threatening infections worldwide. The continued emergence of multiple-antibiotic resistant strains of S. aureus, especially methicillin and vancomycin-intermediate resistant strains, is of significant public health concern. This organism has evolved into a series of two-component signal transduction systems (TCS) in order to sense its immediate surroundings and to modulate cellular responses and the expression of virulence genes. This group’s long-term goals are to elucidate the regulatory mechanisms controlling the expression of genes involved in critical pathways in order to identify novel targets for delivering efficacious preventive and/or therapeutic agents against S. aureus.  The specifichypothesisis that a novel S. aureus TCS (yhcSR) controls the genes/operons required for bacterial growth. The objectives of this project are to characterize the yhcSR system, identify genes/operons that are controlled by yhcSR, and determine the genes/operons that yhcSR directly regulates, which are required for bacterial survival.

Group Members

Jeffrey Hall, Graduate Student
Ting Lei, Graduate Student