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Research Abstracts Online
January 2010 - March 2011

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University of Minnesota Duluth
Swenson College of Science and Engineering
Department of Chemistry and Biochemistry

PI: Joseph L. Johnson

Structure-Function Studies on BACE1 and BACE2

BACE1 is one of the aspartyl proteases responsible for the production of beta-amyloid protein, eventually leading to the formation of Alzheimer's disease. These researchers investigate the structure-function relationships between BACE1 and its protein substrates in order to design therapeutics that target this enzyme. To increase their understanding of BACE1, they also study the closely related BACE2 aspartyl protease. These studies utilize techniques in molecular biology, cell biology, molecular modeling, bioinformatics, and several biophysical methods. The ultimate goal of this research is to gain a deeper understanding of the nature of protein-protein interactions.

Group Members

Brandy R. Aman, Undergraduate Student
Chris L. Bicknese, Undergraduate Student
Nicole Heinks, Undergraduate Student
Andrea M. Newgren, Undergraduate Student