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Research Abstracts Online
January 2010 - March 2011

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University of Minnesota Twin Cities
College of Pharmacy
Department of Medicinal Chemistry

PI: Rodney L. Johnson

Design of Peptidomimetics of the Dopamine Receptor Modulator Pro-Leu-Gly-NH2

These researchers designed and synthesized conformationally constrained peptidomimetics of the dopamine receptor Pro-Leu-Gly-NH2. The peptidomimetics were used to construct a pharmacophore model of the modulatory site. Peptidomimetic photoaffinity labeling agents were made in order to label the modulatory binding site and to use the G protein-coupled receptor model of the dopamine receptor to identify the modulatory site on the receptor.

Group Member

Satyendra Mishra, Research Associate