Research Abstracts Online
January 2010 - March 2011
University of Minnesota Twin Cities
PI: Rosemary F. Kelly
Bioenergetic Adaptations of the Mitochondria in Revascularized Chronic Hibernating Myocardium
One therapeutic modality for humans with myocardial dysfunction secondary to ischemic cardiac disease is revascularization via coronary artery bypass graft (CABG) surgery. After revascularization, the myocardial dysfunction often improves; however, the cellular mechanisms leading to clinical improvement are largely unknown. A swine model of chronically ischemic myocardium, created by gradual left anterior descending coronary artery occlusion, has shown that as chronic ischemia progresses mitochondrial protein profiles and cardiac function change. This group’s objectives are to evaluate the physiologic, bioenergetic, and proteomic changes that occur after revascularization of the hibernating myocardial model.
Recent results indicate that, in hibernating myocardium that has been successfully revascularized, myocardial blood flow during an increased work state is lower than remote regions. Expression of mitochondrial electron transport chain proteins in the revascularized hibernating region is depressed and may provide insight into persistent abnormalities in maximal oxygen consumption within hibernating myocardial tissue.
Jesus Cabrera, Research Associate
Francesca Mazzulla, Undergraduate Student
Edward O. McFalls, Faculty Collaborator
Joe Sikora, Research Associate
Elizabeth Ziemba, Graduate Student