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Research Abstracts Online
January 2010 - March 2011

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University of Minnesota Twin Cities
College of Food, Agricultural, and Natural Resource Sciences
Department of Food Science and Nutrition

PI: Mindy S. Kurzer

Proteomics for SoyCaP Trial

The role of soy isoflavones in prostate cancer prevention is an area of active study. Research suggests that the soy isoflavonoids are an important and perhaps primary group of bioactive compounds in soy that exert these protective effects, but data on the effects of soy isoflavonoids on the prostate tissue is limited. The main aim of this study is to assess the effects of a soy intervention on prostatic protein expression in men at high risk for prostate cancer. The subjects received either: a soy protein isolate (SPI) with 107 ± 5 mg isoflavones aglycone equivalents per day; SPI largely devoid of isoflavones; or milk protein as a placebo. Relative protein expression in post-intervention biopsy samples of these three groups were determined and proteins were identified. The researchers have found that several of the proteins altered by the soy interventions interacted with the nuclear-factor kappa B complex and inflammatory/immune proteins. These data provide mechanistic insight into potential chemopreventive effects of soy. The researchers are planning to publish these results and are continue to use MSI resources to validate their data.

Group Members

Joel W. Slaton, Co-Principal Investigator
Salome A. Rebello, Graduate Student
Michael Wachter, Staff