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Research Abstracts Online
January 2010 - March 2011

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University of Minnesota Twin Cities
College of Pharmacy
Department of Experimental and Clinical Pharmacology

PI: Jatinder K. Lamba

Pharmacogenomics of Nucleoside Analogs

This research is focused on identifying and studying the genetic variations within the key candidate genes in the pharmacokinetic and pharmacodynamic pathways of different anticancer nucleoside analogs, such as cytarabine, gemcitabine, and clofarabine. The project involves extensive genome sequencing and uses resources at the CGL. The researchers also perform genome-wide studies to identify predictors of drug response and toxicity.

Group Members

Tanya Feldberg, Staff
Yogita Ghodke, Research Associate
Michael A. Hart, Graduate Student
Amit Kumar Mitra, Research Associate
Leslie J. Smith, Graduate Student