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Research Abstracts Online
January 2010 - March 2011

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University of Minnesota Twin Cities
Medical School
Department of Medicine

PI: Carol A. Lange

Phosphorylated, SUMO-Deficient, Progesterone Receptors Regulate Transcriptional Activity via Targeting Selected Promoters in Breast Cancer Cells

Progesterone receptors (PRs) mediate proliferation in developing mammary tissue and contribute to breast cancer progression. Elevated expression and activity of epidermal growth factor (EGF) receptor family members frequently occur in advanced breast cancer and these receptors undergo extensive cross-talk with PR signaling. Growth factor-induced kinases regulate PR post-translational modification, such as phosphorylation, ubiquitination, and sumoylation. These researchers hypothesize that reversible attachment of SUMO molecules in response to phosphorylation events dramatically alters PR transcriptional activity and promoter selectivity, and may account for functional differences between PR-A and PR-B isoforms. The researchers are using the CGL for this project.

Group Members

Christy R. Hagan, Research Associate
Todd P. Kutson, Graduate Student