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Research Abstracts Online
January 2010 - March 2011

Main TOC

University of Minnesota Twin Cities
Medical School
Department of Orthopaedic Surgery

PI: Jack L. Lewis, Associate Fellow

Myogenic Potential of Extraocular Muscle Satellite Cells

The extraocular muscles are spared in a number of muscular dystrophies. This lab’s working hypothesis is that this is due to the presence of an expanded or unique muscle progenitor cell. The researchers are trying to molecularly characterize a target myogenic precursor cell, thus far identified as positive for CD34 and negative for Sca1, CD45, CD31, and m-cadherin. This precursor cell type is retained in greater percentages in adult eye muscles compared to limb muscle, and is also retained in the eye muscles of mice models of muscular dystrophy.

Group Members

Mark L. Daniel, Staff
Sadie J. Hebert, Research Associate
Abby A. McDonald, Graduate Student