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Research Abstracts Online
January 2010 - March 2011

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University of Minnesota Twin Cities
College of Veterinary Medicine
Department of Veterinary Clinical Sciences

PI: Jody P. Lulich

Hyperuricosuria Without Alterations in Liver Function as a Risk Factor for Feline Urate Urolithiasis

Although urate represents the third most common stone type in cats, urateuroliths exhibit the highest rate of recurrence (13% in 22 months). In dogs, mutation of the urate transporter (SLC2A9) and portovascular anomalies are common risk factors. The underlying cause for urate urolith formation in cats is poorly understood. These researchers hypothesize that hyperuricosuria without alterations in liver function are common in cats with urate uroliths. NMR samples of these cats are being examined to look for common metabolites (uric acid, allantoin, xanthine) and purine precursors present in the urine. 

Group Member

Catherine M. Rivara, Graduate Student