Research Abstracts Online
January 2010 - March 2011
University of Minnesota Twin Cities
PI: David Masopust
Maximizing CD8 Cells for Protection
These researchers are probing how the memory T cell fate decision is made, how the memory T cell population is regulated and maintained, and the potential of the vertebrate adaptive immune system to undergo increased levels of expansion, in mouse models of heterologous prime boost vaccination. As a result of these studies, the researchers have discovered that the memory fate decision is intimately associated with environment, precursor frequency, and number of cell divisions. They have developed novel systems to alter these variables, which results in effector T cells with different phenotypes, and different potential to establish long-lived protective immunity. They are currently profiling gene expression among effectors cells that have varying potential to establish long-lived immunity, which will provide novel insight into the transcriptional regulation of memory T cell development. They use GeneSpring software, which is critical for the analysis of gene expression data that will be acquired in this study.
Katy Fraser, Research Associate