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Research Abstracts Online
January 2010 - March 2011

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University of Minnesota Twin Cities
College of Biological Sciences
Medical School
Department of Biochemistry, Molecular Biology, and Biophysics

PI: Kevin H. Mayo, Fellow

Protein-Protein and Peptide-Peptide Interactions

Two galectins, galectin-1 and galectin-7, are implicated in the development of cancer and therefore are important targets in the field of drug design. They also are well-known carbohydrate-binding proteins that have a preference to galactosides. All galectins exist as dimmers. These researchers have studied experimentally the binding of several different carbohydrates to galectin-1 and –7, and found out that they bind one of the basic carbohydrates, lactose, with a negative cooperativity. In this project, they are testing the negative cooperativity in binding carbohydrates by galectin-1 and -7 computationally. They are tracking the cross-talk between two binding sites on either protein and determining the residues that are involved to suggest mutations for further experimental studies.

Group Members

Vladimir A. Daragan, Faculty Collaborator
Ruud Dings, Research Associate
Elena Ermakova, Kazan Institute of Biochemistry and Biophysics, Kazan, Russia
Michelle Miller, Graduate Student
Irina Nesmelova, Department of Physics and Optical Science, University of North Carolina, Charlotte, North Carolina
Yuk Sham, Faculty Collaborator