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Research Abstracts Online
January 2010 - March 2011

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University of Minnesota Twin Cities
Medical School
Department of Laboratory Medicine and Pathology

PI: James B. McCarthy

NG2 and CD44 Related Microarray Data Analysis

Proteoglycan molecules play an integral part in tumor cell development, migration, and metastasis. Ongoing studies by the McCarthy laboratory are examining further the function and importance of two proteoglycans, CD44 and NG2, in the development and growth of a number of tumor types. Previously they have generated microarray data looking at immortalized tumor cell lines that differentially express these different genes to examine potential functions and interacting partners/pathways for these molecules. Current work on these projects entails the use of data-analysis software, in particular Genespring and IPA, to characterize the importance of CD44 and NG2 expression in tumor cell function and signaling, with the goal of identifying targets for potential NG2 or CD44 related cancer therapies.

Group Members

Jennifer H. Carlson, Graduate Student
Matthew A. Price, Staff
Jianbo Yang, Research Associate