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Research Abstracts Online
January 2010 - March 2011

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University of Minnesota Twin Cities
Medical School
Department of Integrative Biology and Physiology

PI: Joseph M. Metzger

Cardiac Molecular Engineering

Different isoforms of thin filament proteins within the context of the heart result in marked differences in the contractile performance. This group’s research has shown that critical regulatory domains of these proteins are of utmost importance in influencing this function. The researchers are studying the phylogenetic relationship between isoforms of these proteins across species to understand the relative homology between these isoforms across organisms. This will provide crucial insight into the importance of specific amino acids thus establishing a basis for the conservation or lack of conservation of certain domains throughout evolutionary history. Sequence alignment and phylogenetic trees generated using software through MSI are required for this assessment.

Group Members

DeWayne Townsend, Co-Principal Investigator
Joshua Martindale, Research Associate
Nathan Palpant, Graduate Student
Brian Thompson, Research Associate