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Research Abstracts Online
January 2010 - March 2011

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University of Minnesota Twin Cities
Medical School
Department of Medicine

PI: Jeffrey S. Miller

The Role of MicroRNAs in Human NK Cell Development

Posttranscriptional control of gene expression through microRNAs has emerged as a major mediator of development and function throughout the immune system. This group’s hypothesis is that specific microRNAs are critical for human NK cell development and effector functions in response to activating stimuli. They have collaborated with Aaron Becker in the Genomics Center to carry out microarrays using RNA from NK cell lines transduced with microRNA constructs in an attempt to identify relevant target genes. They are using MSI resources to analyze this data.

Group Members

Frank Cichocki, Graduate Student
Todd Lenvik, Research Associate