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Research Abstracts Online
January 2010 - March 2011

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University of Minnesota Twin Cities
College of Veterinary Medicine
Department of Veterinary Clinical Sciences

PI: Jaime Modiano

Comparative Cancer Genetics

Comparative approaches using naturally occurring tumors of dogs, mice, and humans provide opportunities to discover evolutionarily conserved molecular abnormalities that contribute to the origin and progression of tumors. These researchers have documented such abnormalities in cytogenetically stable and cytogenetically chaotic tumors. They are now using high-throughput, genome-wide technologies to integrate aberrations that occur in the germ line, in the tumor genome, and in the tumor transcriptome to define functionally significant molecular subgroups of cancer for osteosarcoma, non-Hodgkin lymphoma, soft tissue sarcomas (hemangiosarcoma), melanoma, and other tumors. These data will be further integrated with pharmacogenomic approaches to validate the biological and therapeutic relevance of previously uncharacterized abnormalities.

Group Members

Megan Duckett, Staff
Aric Frantz, Graduate Student
Sarah Highfill, Staff
Daisuke Ito, Research Associate
Timothy O’Brien, Faculty Collaborator
Tzu Lip Phang, Pulmonary Science and Critical Care Medicine, University of Colorado Denver, Denver, Colorado
Sally Robinson, Graduate Student
Aaron Sarver, Research Associate
Milcah Scott, Staff
Leslie Sharkey, Faculty Collaborator
Kevin A.T. Silverstein, Faculty Collaborator