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Research Abstracts Online
January 2010 - March 2011

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University of Minnesota Twin Cities
College of Biological Sciences
Medical School
Department of Genetics, Cell Biology, and Development

PI: Mary E. Porter

Assembly, Targeting, and Regulation of Dynein Motors

Dyneins are microtubule-based motors involved in intracellular transport and flagellar motility. Cilia and flagella play critical roles in human health and disease, and defects in the activities of dynein motors can lead to infertility, chronic respiratory disease, and birth defects. These researchers study how dynein motors are assembled, transported, and regulated in the unicellular alga Chlamydomonas. Given that the structure of the flagellar axoneme is highly conserved, these studies have implication for cilia-related diseases in humans. The researchers use the programs at MSI to analyze the DNA sequences of the different genes and images of cells obtained by light and electron microscopy.

Group Members

Raqual Bower, Staff
Paula Soneral, Department of Chemistry, Crown College, St. Bonifacus, Minnesota
Doug Tritschler, Staff
Kristyn VanderWaal Mills, Graduate Student